Significance and Meaning of Neurological Signs in Schizophrenia: Two Decades Later
نویسندگان
چکیده
منابع مشابه
Significance and meaning of neurological signs in schizophrenia.
The authors review studies of abnormal signs on clinical neurological examination of schizophrenic patients. In spite of a number of methodologic limitations, the cumulative evidence strongly argues that there are more neurological signs in schizophrenic patients than in nonpsychiatric control subjects. Although less consistent, there is considerable evidence of more neurological signs in schiz...
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Two decades ago we reviewed contributions of investigations based on neurological mutant mice to our understanding of the development of cortical structures of the central nervous system (Caviness and Rakic, 1978). At the time, there was an air of optimism that such mutations, occurring at a single genetic locus, might enable a"genetic dissection" of molecular mechanisms of regulation of brain ...
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Declaration of interest None. Funding fromthe Stanley Foundation and the Medical Research Council (UK). Neurological soft signs (NSS) are minor (‘soft’) neurological abnormalities in sensory and motor performance identified by clinical examination. They have been described in excess in patients with schizophrenia (Buchanan & Heinrichs, 1989). There is still a lack of consensus on the neurodysfu...
متن کاملNeurological Soft Signs in First -Episode Schizophrenia
Neurological soft signs (NSS) refer to subtle neurological abnormalities comprising deficits in sensory integration, motor coordination, or sequencing of complex motor acts. It is generally accepted that NSS are more prevalent in schizophrenia patients, including first -episode cases, than in healthy subjects. Moreover, NSS have been consistently demonstrated in neuroleptic naïve firstepisode p...
متن کاملPotential endophenotype for schizophrenia: neurological soft signs.
INTRODUCTION Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. METHODS This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotyp...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2005
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbi028